The weather forecast gave a 90 percent chance for favourable conditions to blast off at the projected time of 7.17 am (1117 GMT, 7.17pm Singapore time) from Cape Canaveral in Florida, a Nasa spokesman said.
Nasa was set late on Friday to prepare the seven crew members for boarding and begin filling the shuttle's external tank with some two million litres of chilled liquid hydrogen fuel.
If everything goes to plan officials said the shuttle would return next Friday at 9:15 pm (0115 GMT Saturday).
Construction began on the ISS a decade ago, and the push is on to complete the building before Nasa ends its shuttle missions in September 2010.
Endeavour's crew are tasked with installing the final elements of the Japanese laboratory Kibo during their 16-day mission. The station has become a sophisticated platform for scientific experiments after the installation of a European laboratory last year and the arrival of the hi-tech Japanese lab that is currently being completed.
It will be the 32nd mission to the ISS, which orbits 350 kilometres above Earth, and the last of three missions to assemble the Kibo laboratory.
Over the five planned spacewalks lasting some 32.5 hours, the astronauts will install a permanent 1.9 tonnes platform to Kibo, which will serve as one of the station's porches for conducting experiments in the vacuum of space.
Endeavour will also deliver a large number of spare equipment, and bring up an unpressurised storage area for keeping the experiments that have been exposed to the extremes of space.
It will also bring with it another platform that can be unfixed from the space station and then flown back to Earth in the Endeavour's cargo hold.
Nasa is seeking to make maximum use of its flights to the space station with only another seven planned after the Endeavour's trip before the shuttles are retired. -- AFP
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